OPRK1 - opioid receptor kappa 1 Gene

Homo sapiens

Also known as KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1

Gene ID: 4986 | Gene type: protein coding

About OPRK1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,225,724-53,251,637 (from NCBI)

This gene has 5 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues.

Summary

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

OPRK1 Products(3)

mRNA	Protein	Name
NM_000912.5	NP_000903.2	kappa-type opioid receptor isoform 1
NM_001282904.2	NP_001269833.1	kappa-type opioid receptor isoform 2
NM_001318497.2	NP_001305426.1	kappa-type opioid receptor isoform 1x

OPRK1 Protein Structure

7tm_1

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

kappa-type opioid receptor

Opiate receptor, kappa-1

Related Diseases

Diseases

Alias

Morphine Dependence

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Cocaine Dependence

Opiate Dependence

Opioid Dependence	Opioid Addiction
Opiate Addiction	Opioid Type Dependence
Opioid-Related Disorders	Opium Dependence
Narcotic Dependence	Intravenous Narcotism
Narcotism Nos	Oral Narcotism Nos

Drug Dependence

Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn

Opioid Abuse

Opioid-Related Disorders

Cocaine Abuse

Cocaine-Related Disorders

Pain Agnosia

Analgesia

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Retinitis Pigmentosa 44

RP44	Retinitis Pigmentosa, Type 44

Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23	SCA23
Ataxia, Spinocerebellar, Type 23

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Substance Dependence

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Specific Developmental Disorder

Constipation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09802	OPRK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OPRK1	VGNC	VGNC:68633
Bos taurus	OPRK1	VGNC	VGNC:32439
Canis familiaris	OPRK1	VGNC	VGNC:44133
Macaca mulatta	OPRK1	VGNC	VGNC:104467
Rattus norvegicus	OPRK1	RGD	RGD:69426
Mus musculus	OPRK1	MGD	MGI:97439

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