2. Gene
  3. ATP5F1B - ATP synthase F1 subunit beta Gene

ATP5F1B - ATP synthase F1 subunit beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATP5B; ATPMB; ATPSB; HUMOP2; HEL-S-271

Gene ID: 506 | Gene type: protein coding

About ATP5F1B

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,638,175-56,645,984 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 713.8), kidney (RPKM 376.0) and 25 other tissues.

Summary

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

ATP5F1B Products(1)

mRNA Protein Name
NM_001686.4 NP_001677.2 ATP synthase subunit beta, mitochondrial precursor

ATP5F1B Protein Structure

ATP-synt_ab_N

ATP-synt_ab_N: ATP synthase alpha/beta family, beta-barrel domain (63 - 129)

ATP-synt_ab

ATP-synt_ab: ATP synthase alpha/beta family, nucleotide-binding domain (185 - 405)

ATP-synt_ab_C

ATP-synt_ab_C: ATP synthase alpha/beta chain, C terminal domain (418 - 521)

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  • 529 a.a.
Protein Preferred Names Protein Names

ATP synthase subunit beta, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

Recombinant ATP5F1B Proteins

Cat. No. Product Name Accession Purity
HY-P71716 ATP5F1B Protein, Human (P.pastoris, His) P06576 (48A-529S) ≥95%

Related Diseases

Diseases Alias
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01203 ATP5F1B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP5F1B MGD MGI:107801
Rattus norvegicus ATP5F1B RGD RGD:621368
Bos taurus ATP5F1B VGNC VGNC:26300
Felis catus ATP5F1B VGNC VGNC:83505
Others ATP5F1B NCBI