IRX4 - iroquois homeobox 4 Gene

Homo sapiens

Also known as IRXA3

Gene ID: 50805 | Gene type: protein coding

About IRX4

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,877,413-1,887,179 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues and 6 paralogues. Biased expression in prostate (RPKM 2.5), skin (RPKM 2.0) and 3 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within heart development. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

IRX4 Products(5)

mRNA	Protein	Name
NM_001278632.1	NP_001265561.1	iroquois-class homeodomain protein IRX-4 isoform b
NM_001278633.1	NP_001265562.1	iroquois-class homeodomain protein IRX-4 isoform a
NM_001278634.2	NP_001265563.1	iroquois-class homeodomain protein IRX-4 isoform b
NM_001278635.2	NP_001265564.1	iroquois-class homeodomain protein IRX-4 isoform a
NM_016358.3	NP_057442.1	iroquois-class homeodomain protein IRX-4 isoform b

IRX4 Protein Structure

Homeobox_KN

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

iroquois-class homeodomain protein IRX-4

homeodomain protein IRXA3

Related Diseases

Diseases

Alias

Hypoplastic Left Heart Syndrome

Hlhs	Heart, Hypoplastic Left, Syndrome
Hypoplasia Of The Left Heart	Left Heart Hypoplasia Syndrome
Hlhs - [Hypoplastic Left Heart Syndrome]	Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome
Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome	Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle
Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia	Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome
Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06923	IRX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IRX4	VGNC	VGNC:67832
Macaca mulatta	IRX4	VGNC	VGNC:73768
Mus musculus	IRX4	MGD	MGI:1355275
Rattus norvegicus	IRX4	RGD	RGD:1309309
Canis familiaris	IRX4	VGNC	VGNC:54102
Bos taurus	IRX4	VGNC	VGNC:30288

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