PARD6A - par-6 family cell polarity regulator alpha Gene

Homo sapiens

Also known as PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

Gene ID: 50855 | Gene type: protein coding

About PARD6A

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,660,960-67,662,774 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 2 paralogues. Broad expression in testis (RPKM 9.8), brain (RPKM 5.0) and 23 other tissues.

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

PARD6A Products(2)

mRNA	Protein	Name
NM_001037281.2	NP_001032358.1	partitioning defective 6 homolog alpha isoform 2
NM_016948.3	NP_058644.1	partitioning defective 6 homolog alpha isoform 1

PARD6A Protein Structure

PB1

PDZ

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

partitioning defective 6 homolog alpha

PAR-6 alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10038	PARD6A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PARD6A	VGNC	VGNC:44265
Mus musculus	PARD6A	MGD	MGI:1927223
Rattus norvegicus	PARD6A	RGD	RGD:1303273
Felis catus	PARD6A	VGNC	VGNC:64041
Bos taurus	PARD6A	VGNC	VGNC:32583
Macaca mulatta	PARD6A	VGNC	VGNC:104743

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