DERL2 - derlin 2 Gene

Homo sapiens

Also known as FLANa; F-LANa; CGI-101; F-LAN-1; derlin-2; DERtrin-2

Gene ID: 51009 | Gene type: protein coding

About DERL2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,471,254-5,486,817 (from NCBI)

This gene has 13 transcripts (splice variants), 134 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 7.8) and 25 other tissues.

Summary

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]

DERL2 Products(3)

mRNA	Protein	Name
NM_001304777.2	NP_001291706.1	derlin-2 isoform b
NM_001304779.2	NP_001291708.1	derlin-2 isoform c
NM_016041.5	NP_057125.2	derlin-2 isoform a

DERL2 Protein Structure

DER1

0
100
200
239 a.a.

Protein Preferred Names

Protein Names

derlin-2

Der1-like domain family, member 2

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Hepatosplenic T-Cell Lymphoma

Doid:0081049

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03700	DERL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DERL2	VGNC	VGNC:39903
Macaca mulatta	DERL2	VGNC	VGNC:71654
Mus musculus	DERL2	MGD	MGI:2151483
Bos taurus	DERL2	VGNC	VGNC:28011
Felis catus	DERL2	VGNC	VGNC:61449
Rattus norvegicus	DERL2	RGD	RGD:6496100

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