2. Gene
  3. TXNDC12 - thioredoxin domain containing 12 Gene

TXNDC12 - thioredoxin domain containing 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19

Gene ID: 51060 | Gene type: protein coding

About TXNDC12

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,020,131-52,056,171 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 12.7), thyroid (RPKM 11.7) and 25 other tissues.

Summary

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

TXNDC12 Products(1)

mRNA Protein Name
NM_015913.4 NP_056997.1 thioredoxin domain-containing protein 12 precursor

TXNDC12 Protein Structure

Thioredoxin_7

Thioredoxin_7: Thioredoxin-like (40 - 120)

  • 0
  • 100
  • 172 a.a.
Protein Preferred Names Protein Names

thioredoxin domain-containing protein 12

ER protein 18

Recombinant TXNDC12 Proteins

Cat. No. Product Name Accession Purity
HY-P71046 TXNDC12 Protein, Human (HEK293, His) O95881 (H27-L168) ≥95%

Related Diseases

Diseases Alias
Discitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15290 TXNDC12 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TXNDC12 VGNC VGNC:48011
Felis catus TXNDC12 VGNC VGNC:66725
Bos taurus TXNDC12 VGNC VGNC:36535
Rattus norvegicus TXNDC12 RGD RGD:1305960
Mus musculus TXNDC12 MGD MGI:1913323
Others TXNDC12 NCBI