TNNI3K - TNNI3 interacting kinase Gene

Homo sapiens

Also known as CARK; CCDD

Gene ID: 51086 | Gene type: protein coding

About TNNI3K

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:74,235,387-74,544,428 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues, 23 paralogues and is associated with 2 phenotypes. Biased expression in heart (RPKM 19.3), testis (RPKM 1.3) and 1 other tissue.

Summary

This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]

TNNI3K Products(1)

mRNA	Protein	Name
NM_015978.3	NP_057062.1	serine/threonine-protein kinase TNNI3K

TNNI3K Protein Structure

Ank_2

Pkinase_Tyr

0
200
400
600
835 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase TNNI3K

cardiac ankyrin repeat kinase

Related Diseases

Diseases

Alias

Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy

CCDD	Familial Atrial Tachyarrhythmia-Infra-Hisian Cardiac Conduction Disease
Cardiac Conduction Disease With/Without Dilated Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia, Familial, 2

Arrhythmogenic Right Ventricular Dysplasia 2	ARVD2
Arrhythmogenic Right Ventricular Cardiomyopathy 2	Arvc2
Familial Arrhythmogenic Right Ventricular Dysplasia 2	Dysplasia, Arrhythmogenic Right Ventricular, Type 2

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119608	GSK854		98.40%	Unkown
HY-117243	GSK329		99.60%	Unkown
HY-117658	GSK-114	Inhibitor	98.08%	Unkown
HY-RS14853	TNNI3K Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNNI3K	RGD	RGD:727908
Mus musculus	TNNI3K	MGD	MGI:2443276

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