METTL9 - methyltransferase like 9 Gene

Homo sapiens

Also known as DREV; PAP1; DREV1; CGI-81; hMETTL9

Gene ID: 51108 | Gene type: protein coding

About METTL9

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:21,597,208-21,657,471 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele and 199 orthologues. Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues.

Summary

Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

METTL9 Products(4)

mRNA	Protein	Name
NM_001077180.3	NP_001070648.1	protein-L-histidine N-pros-methyltransferase isoform 2 precursor
NM_001288659.2	NP_001275588.1	protein-L-histidine N-pros-methyltransferase isoform 3
NM_001288660.2	NP_001275589.1	protein-L-histidine N-pros-methyltransferase isoform 4
NM_016025.5	NP_057109.3	protein-L-histidine N-pros-methyltransferase isoform 1 precursor

METTL9 Protein Structure

DREV

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

protein-L-histidine N-pros-methyltransferase

CTB-31N19.3

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 22

DFNB22	Autosomal Recessive Nonsyndromic Deafness 22
Autosomal Recessive Deafness 22	Deafness, Autosomal Recessive, 22
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 22	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 22

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08371	METTL9 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	METTL9	VGNC	VGNC:31418
Mus musculus	METTL9	MGD	MGI:1914862
Macaca mulatta	METTL9	VGNC	VGNC:74568
Canis familiaris	METTL9	VGNC	VGNC:43183
Felis catus	METTL9	VGNC	VGNC:97507
Rattus norvegicus	METTL9	RGD	RGD:2311609

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