DBR1 - debranching RNA lariats 1 Gene

Homo sapiens

Gene ID: 51163 | Gene type: protein coding

About DBR1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,160,988-138,174,921 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in stomach (RPKM 5.7), bone marrow (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA lariat debranching Enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

DBR1 Products(1)

mRNA	Protein	Name
NM_016216.4	NP_057300.2	lariat debranching enzyme

DBR1 Protein Structure

Metallophos

DBR1

0
100
200
300
400
500
544 a.a.

Protein Preferred Names

Protein Names

lariat debranching enzyme

RNA lariat debranching enzyme

Related Diseases

Diseases

Alias

Encephalitis, Acute, Infection -Induced 11

IIAE11	Encephalitis, Acute, Infection -Induced, Susceptibility To, 11
Encephalitis, Acute, Infection -Induced, 11

Viral Encephalitis

Epidemic Encephalitis	Encephalitis Viral
Encephalitis, Arbovirus	Arbovirus Encephalitis
Postviral Encephalitis Nos	Equine Encephalitis
Tick-Borne Encephalitis	Viral Encephalitis Transmitted By Tick
Mosquito-Borne Encephalitis	Acute Haemorrhagic Encephalitis
Acute Idiopathic Encephalitis	Chronic Viral Encephalitis
Endemic Encephalitis	Subacute Viral Encephalitis
Viral Haemorrhagic Encephalitis	Viral Nonepidemic Encephalitis
Nonepidemic Encephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156744	DBr-1	Degrader	/	Unkown
HY-RS03553	DBR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DBR1	VGNC	VGNC:61350
Macaca mulatta	DBR1	VGNC	VGNC:71626
Rattus norvegicus	DBR1	RGD	RGD:1598038
Bos taurus	DBR1	VGNC	VGNC:27895
Canis familiaris	DBR1	VGNC	VGNC:39786
Mus musculus	DBR1	MGD	MGI:1931520

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