HAO2 - hydroxyacid oxidase 2 Gene

Homo sapiens

Also known as GIG16; HAOX2

Gene ID: 51179 | Gene type: protein coding

About HAO2

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:119,368,785-119,394,130 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 2 paralogues. Biased expression in kidney (RPKM 63.1) and liver (RPKM 51.5).

Summary

This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

HAO2 Products(3)

mRNA	Protein	Name
NM_001005783.3	NP_001005783.2	2-Hydroxyacid oxidase 2 isoform 2
NM_001377472.1	NP_001364401.1	2-Hydroxyacid oxidase 2 isoform 3
NM_016527.4	NP_057611.1	2-Hydroxyacid oxidase 2 isoform 1

HAO2 Protein Structure

FMN_dh

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

2-Hydroxyacid oxidase 2

(S)-2-hydroxy-acid oxidase, peroxisomal

Related Diseases

Diseases

Alias

Histidinemia

Histidine Ammonia-Lyase Deficiency	Hal Deficiency
Histidase Deficiency	His Deficiency
Histidinuria	Hyperhistidinemia
HISTID	Histidinuria Renal Tubular Defect

Histidine Metabolism Disease

Disturbances Of Histidine Metabolism	Disorder Of Histidine Metabolism
Disturbance Of Histidine Metabolism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05999	HAO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HAO2	VGNC	VGNC:81416
Canis familiaris	HAO2	VGNC	VGNC:41591
Rattus norvegicus	HAO2	RGD	RGD:70972
Bos taurus	HAO2	VGNC	VGNC:29748
Mus musculus	HAO2	MGD	MGI:96012
Felis catus	HAO2	VGNC	VGNC:80227

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