PCP4 - Purkinje cell protein 4 Gene

Homo sapiens

Also known as PEP-19

Gene ID: 5121 | Gene type: protein coding

About PCP4

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,867,438-39,929,392 (from NCBI)

This gene has 4 transcripts (splice variants), 166 orthologues and 1 paralogue. Biased expression in prostate (RPKM 108.8), urinary bladder (RPKM 73.3) and 6 other tissues.

Summary

Enables calcium ion binding activity and Calmodulin binding activity. Involved in Calmodulin dependent kinase signaling pathway and positive regulation of neuron differentiation. Located in cytosol and nucleus. Part of protein-containing complex. Biomarker of Huntington's disease and leiomyoma. [provided by Alliance of Genome Resources, Apr 2022]

PCP4 Products(1)

mRNA	Protein	Name
NM_006198.3	NP_006189.2	calmodulin regulator protein PCP4

Protein Preferred Names

Protein Names

calmodulin regulator protein PCP4

brain specific polypeptide PEP19

Related Diseases

Diseases

Alias

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Autoimmune Atherosclerosis

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10168	PCP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10169	PCP4L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PCP4	VGNC	VGNC:84749
Felis catus	PCP4	VGNC	VGNC:102802
Mus musculus	PCP4	MGD	MGI:97509
Rattus norvegicus	PCP4	RGD	RGD:3271
Canis familiaris	PCP4	VGNC	VGNC:44319
Bos taurus	PCP4	VGNC	VGNC:106858

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