CRNKL1 - crooked neck pre-mRNA splicing factor 1 Gene

Homo sapiens

Also known as CLF; CRN; Clf1; HCRN; SYF3; MSTP021

Gene ID: 51340 | Gene type: protein coding

About CRNKL1

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,034,368-20,056,046 (from NCBI)

This gene has 7 transcripts (splice variants), 219 orthologues, 2 paralogues and is associated with 64 phenotypes. Ubiquitous expression in bone marrow (RPKM 8.6), testis (RPKM 8.2) and 25 other tissues.

Summary

The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]

CRNKL1 Products(5)

mRNA	Protein	Name
NM_001278625.2	NP_001265554.1	crooked neck-like protein 1 isoform b
NM_001278626.2	NP_001265555.1	crooked neck-like protein 1 isoform c
NM_001278627.2	NP_001265556.1	crooked neck-like protein 1 isoform c
NM_001278628.2	NP_001265557.1	crooked neck-like protein 1 isoform d
NM_016652.6	NP_057736.4	crooked neck-like protein 1 isoform a

CRNKL1 Protein Structure

HAT

0
200
400
600
800
848 a.a.

Protein Preferred Names

Protein Names

crooked neck-like protein 1

Crn, crooked neck-like 1

Related Diseases

Diseases

Alias

Skin Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Skin	Epidermoid Skin Carcinoma
Squamous Cell Carcinoma Of The Skin	Squamous Cell Epithelioma Of Skin
Cutaneous Squamous Cell Carcinoma	Scc - [Squamous Cell Carcinoma] Of Skin

Skin Melanoma

Cutaneous Melanoma	Malignant Ear Melanoma
Malignant Lip Melanoma	Malignant Lower Limb Melanoma
Malignant Melanoma Of Ear And/Or External Auricular Canal	Malignant Melanoma Of Skin Of Lower Limb
Malignant Melanoma Of Skin Of Trunk Except Scrotum	Malignant Melanoma Of Skin Of Upper Limb
Malignant Neck Melanoma	Malignant Scalp Melanoma
Malignant Trunk Melanoma	Malignant Upper Limb Melanoma
Melanoma, Cutaneous Malignant	Melanoma
Malignant Melanoma Of Skin	Melanoma Nos
Malignant Mole, Meaning Melanoma Of Unspecified Site	Melanoma Of Unspecified Site
Cutaneous Malignant Melanoma	Mm - [Malignant Melanoma]

Fanconi Anemia, Complementation Group G

Fanconi Anemia Complementation Group G

FANCG

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03191	CRNKL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CRNKL1	RGD	RGD:620507
Felis catus	CRNKL1	VGNC	VGNC:61187
Macaca mulatta	CRNKL1	VGNC	VGNC:71412
Mus musculus	CRNKL1	MGD	MGI:1914127
Bos taurus	CRNKL1	VGNC	VGNC:27721
Canis familiaris	CRNKL1	VGNC	VGNC:39625

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