HOOK1 - hook microtubule tethering protein 1 Gene

Homo sapiens

Also known as HK1

Gene ID: 51361 | Gene type: protein coding

About HOOK1

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,814,949-59,876,322 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.7), colon (RPKM 10.0) and 21 other tissues.

Summary

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule Cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

HOOK1 Products(1)

mRNA	Protein	Name
NM_015888.6	NP_056972.1	protein Hook homolog 1

HOOK1 Protein Structure

HOOK

0
200
400
600
728 a.a.

Protein Preferred Names

Protein Names

protein Hook homolog 1

h-hook1

Related Diseases

Diseases

Alias

Spermatogenic Failure 16

SPGF16	Acephalic Spermatozoa Syndrome
Spermatozoa, Acephalic

Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome

Metanephric Adenoma

Renal Adenoma

Renal Cell Adenoma

Cranioectodermal Dysplasia 1

Sensenbrenner Syndrome	CED1
Levin Syndrome I	Cranio-Ectodermal Dysplasia
Dysplasia, Cranioectodermal, Type 1	Cranioectodermal Dysplasia

Ceroid Lipofuscinosis, Neuronal, 3

Batten Disease	Juvenile Neuronal Ceroid Lipofuscinosis
Neuronal Ceroid Lipofuscinosis 3	CLN3
Jncl	Spielmeyer-Vogt Disease
Vogt-Spielmeyer Disease	Spielmeyer-Sjogren Disease
Cln3 Disease	Neuronal Ceroid Lipofuscinosis, Juvenile
Cln3 Disease, Juvenile	Spielmeyer Sjogren Disease
Vogt Spielmeyer Disease	Batten-Mayou Disease
Batten-Spielmeyer-Vogt Disease	Cln3-Related Neuronal Ceroid-Lipofuscinosis
Juvenile Batten Disease	Juvenile Cerebroretinal Degeneration
Classic Juvenile Ncl	Classic Juvenile Neuronal Ceroid Lipofuscinosis
Juvenile Ncl	Lipofuscinosis, Ceroid, Neuronal, Type 3

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06287	HOOK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOOK1	MGD	MGI:1925213
Rattus norvegicus	HOOK1	RGD	RGD:1309987
Canis familiaris	HOOK1	VGNC	VGNC:41740
Macaca mulatta	HOOK1	VGNC	VGNC:73424
Bos taurus	HOOK1	VGNC	VGNC:29905
Felis catus	HOOK1	VGNC	VGNC:62832

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