CRLF3 - cytokine receptor like factor 3 Gene

Homo sapiens

Also known as FRWS; CRLM9; p48.2; CREME9; CYTOR4; CREME-9

Gene ID: 51379 | Gene type: protein coding

About CRLF3

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,782,684-30,824,692 (from NCBI)

This gene has 6 transcripts (splice variants), 203 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 15.5), appendix (RPKM 12.1) and 24 other tissues.

Summary

This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

CRLF3 Products(1)

mRNA	Protein	Name
NM_015986.4	NP_057070.3	cytokine receptor-like factor 3

Protein Preferred Names

Protein Names

cytokine receptor-like factor 3

cytokine receptor-like molecule 9

Related Diseases

Diseases

Alias

Neurofibromatosis

Neurofibromatoses	Acoustic Neurofibromatosis
Central Neurofibromatosis	Peripheral Neurofibromatosis
Recklinghausen'S Neurofibromatosis	Von Reklinghausen Disease
Neurofibromatosis Type 1

Actinic Keratosis

Solar Keratosis	Actinic Keratosis
Senile Hyperkeratosis	Sk - Solar Keratosis
Keratosis, Actinic	Seborrheic Keratosis
Ak - [Actinic Keratosis]	Sk - [Solar Keratosis]

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome	17q11 Microdeletion Syndrome
Neurofibromatosis Type 1 Microdeletion Syndrome	Van Asperen Syndrome
Del(17)(Q11)	Monosomy 17q11
Chromosome 17q11.2 Deletion Syndrome, 1.4mb

Chromosome 15q26-Qter Deletion Syndrome

Drayer Syndrome	15q26 Deletion Syndrome
Distal 15q Deletion Syndrome	Distal Monosomy 15q
Telomeric 15q Deletion Syndrome	Monosomy 15q26

Epiphyseal Dysplasia, Multiple, 5

EDM5	Multiple Epiphyseal Dysplasia 5
Bhmed	Multiple Epiphyseal Dysplasia Type 5
Multiple Epiphyseal Dysplasia, Matn3-Related	Microepiphyseal Dysplasia, Bilateral Hereditary
Bilateral Hereditary Microepiphyseal Dysplasia	Multiple Epiphyseal Dysplasia Matn3-Related
Epiphyseal Dysplasia Multiple 5	Multiple Epiphyseal Dysplasia, Matn3 Related
Bilateral Hereditary Micro-Epiphyseal Dysplasia	Med5
Polyepiphyseal Dysplasia Type 5	Dysplasia, Epiphyseal, Multiple, Type 5

Dysgraphia

Agraphia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03188	CRLF3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRLF3	VGNC	VGNC:39622
Felis catus	CRLF3	VGNC	VGNC:61184
Macaca mulatta	CRLF3	VGNC	VGNC:71428
Rattus norvegicus	CRLF3	RGD	RGD:621517
Mus musculus	CRLF3	MGD	MGI:1860086
Bos taurus	CRLF3	VGNC	VGNC:27718

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