2. Gene
  3. GTSE1 - G2 and S-phase expressed 1 Gene

GTSE1 - G2 and S-phase expressed 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B99

Gene ID: 51512 | Gene type: protein coding

About GTSE1

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:46,296,870-46,330,810 (from NCBI)

This gene has 4 transcripts (splice variants), 178 orthologues and 1 paralogue. Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues.

Summary

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce Apoptosis. [provided by RefSeq, Jul 2008]

GTSE1 Products(1)

mRNA Protein Name
NM_016426.7 NP_057510.5 G2 and S phase-expressed protein 1

GTSE1 Protein Structure

GTSE1_N

GTSE1_N: G-2 and S-phase expressed 1 (27 - 171)

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  • 739 a.a.
Protein Preferred Names Protein Names

G2 and S phase-expressed protein 1

G-2 and S-phase expressed 1

Related Diseases

Diseases Alias
Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type

Amcn

Arthrogryposis Multiplex Congenita Neurogenic Type

AMC2

Amc, Neurogenic Type

Neurogenic-Type Arthrogryposis Multiplex Congenita-2

Amc Neurogenic Type

Neurogenic Type Of Amc

Neurogenic Arthrogryposis Multiplex Congenita

Arthrogryposis Multiplex Congenita, Neurogenic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05913 GTSE1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GTSE1 RGD RGD:1563164
Canis familiaris GTSE1 VGNC VGNC:41559
Bos taurus GTSE1 VGNC VGNC:29711
Macaca mulatta GTSE1 VGNC VGNC:73162
Mus musculus GTSE1 MGD MGI:1352755
Felis catus GTSE1 VGNC VGNC:62738