2. Gene
  3. CXXC5 - CXXC finger protein 5 Gene

CXXC5 - CXXC finger protein 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CF5; WID; RINF; HSPC195

Gene ID: 51523 | Gene type: protein coding

About CXXC5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,647,299-139,683,882 (from NCBI)

This gene has 16 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues.

Summary

The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

CXXC5 Products(14)

mRNA Protein Name
NM_001317199.2 NP_001304128.1 CXXC-type zinc finger protein 5
NM_001317200.2 NP_001304129.1 CXXC-type zinc finger protein 5
NM_001317201.2 NP_001304130.1 CXXC-type zinc finger protein 5
NM_001317202.2 NP_001304131.1 CXXC-type zinc finger protein 5
NM_001317203.2 NP_001304132.1 CXXC-type zinc finger protein 5
NM_001317204.2 NP_001304133.1 CXXC-type zinc finger protein 5
NM_001317205.2 NP_001304134.1 CXXC-type zinc finger protein 5
NM_001317206.2 NP_001304135.1 CXXC-type zinc finger protein 5
NM_001317207.2 NP_001304136.1 CXXC-type zinc finger protein 5
NM_001317208.2 NP_001304137.1 CXXC-type zinc finger protein 5
NM_001317209.2 NP_001304138.1 CXXC-type zinc finger protein 5
NM_001317210.2 NP_001304139.1 CXXC-type zinc finger protein 5
NM_001317211.2 NP_001304140.1 CXXC-type zinc finger protein 5
NM_016463.9 NP_057547.5 CXXC-type zinc finger protein 5

CXXC5 Protein Structure

zf-CXXC

zf-CXXC: CXXC zinc finger domain (257 - 296)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

CXXC-type zinc finger protein 5

CXXC finger 5 protein

Related Diseases

Diseases Alias
Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Arthrogryposis, Distal, Type 4

Distal Arthrogryposis Type 4

DA4

Daiid

Arthrogryposis-Severe Scoliosis Syndrome

Distal Arthrogryposis Type Iid

Arthrogryposis With Severe Scoliosis

Arthrogryposis, Distal, Type Iid
Astroblastoma

Cerebral Astroblastoma
Cardiomyopathy, Familial Hypertrophic, 17

Hypertrophic Cardiomyopathy 17

CMH17

Cardiomyopathy, Hypertrophic, 17

Cardiomyopathy Familial Hypertrophic 17

Cardiomyopathy, Familial Hypertrophic 17

Cardiomyopathy, Hypertrophic, Familial, Type 17
Spondyloepiphyseal Dysplasia, Kimberley Type

SEDK

Spondyloepiphyseal Dysplasia Kimberley Type

Spondyloepiphyseal Dysplasia Type Kimberley

Dysplasia, Spondyloepiphyseal, Kimberley Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131447 KY19382 ≥98.0% Unkown
HY-124156A KY-02327 acetate Inhibitor 99.35% Unkown
HY-131448 A3334 Inhibitor 99.86% Unkown
HY-124156 KY-02327 Inhibitor / Unkown
HY-RS03415 CXXC5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CXXC5 VGNC VGNC:71594
Canis familiaris CXXC5 VGNC VGNC:39754
Bos taurus CXXC5 VGNC VGNC:27860
Felis catus CXXC5 VGNC VGNC:61305
Rattus norvegicus CXXC5 RGD RGD:1359466
Mus musculus CXXC5 MGD MGI:1914643