2. Gene
  3. CD244 - CD244 molecule Gene

CD244 - CD244 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 2B4; NAIL; Nmrk; NKR2B4; SLAMF4

Gene ID: 51744 | Gene type: protein coding

About CD244

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,830,160-160,862,887 (from NCBI)

This gene has 5 transcripts (splice variants), 108 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 7.3), bone marrow (RPKM 3.3) and 12 other tissues.

Summary

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

CD244 Products(3)

mRNA Protein Name
NM_001166663.2 NP_001160135.1 natural killer cell receptor 2B4 isoform 2 precursor
NM_001166664.2 NP_001160136.1 natural killer cell receptor 2B4 isoform 3 precursor
NM_016382.4 NP_057466.1 natural killer cell receptor 2B4 isoform 1 precursor

CD244 Protein Structure

Receptor_2B4

Receptor_2B4: Natural killer cell receptor 2B4 (22 - 127)

Ig_2

Ig_2: Immunoglobulin domain (137 - 215)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

natural killer cell receptor 2B4

CD244 molecule, natural killer cell receptor 2B4

Recombinant CD244 Proteins

Cat. No. Product Name Accession Purity
HY-P72745 2B4/CD244 Protein, Human (200a.a, HEK293, His) Q9BZW8-2 (C22-R221) ≥95%
HY-P75556 2B4/CD244 Protein, Human (221a.a, HEK293, Fc) Q9BZW8-2 (M1-R221) ≥95%
HY-P75557 2B4/CD244 Protein, Human (221a.a, HEK293, His) Q9BZW8-2 (M1-R221) ≥95%
HY-P78052 2B4/CD244 Protein, Human (Biotinylated, HEK293, His-Avi) Q9BZW8-2 (C22-R221) ≥95%
HY-P78366 2B4/CD244 Protein, Human (HEK293, Fc) Q9BZW8-2 (C22-R221) ≥95%
HY-P78912 2B4/CD244 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q9BZW8-2 (C22-R221) ≥95%

Related Diseases

Diseases Alias
Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Selective Immunoglobulin Deficiency Disease
Dysgammaglobulinemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02213 CD244 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CD244 MGD MGI:109294
Bos taurus CD244 VGNC VGNC:27015
Rattus norvegicus CD244 RGD RGD:68400
Canis familiaris CD244 VGNC VGNC:53117
Macaca mulatta CD244 VGNC VGNC:70821
Felis catus CD244 VGNC VGNC:60599
Others CD244 NCBI