2. Gene
  3. PLCB2 - phospholipase C beta 2 Gene

PLCB2 - phospholipase C beta 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PLC-beta-2

Gene ID: 5330 | Gene type: protein coding

About PLCB2

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,284,256-40,307,935 (from NCBI)

This gene has 15 transcripts (splice variants), 219 orthologues and 14 paralogues. Broad expression in spleen (RPKM 26.9), bone marrow (RPKM 19.8) and 17 other tissues.

Summary

The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]

PLCB2 Products(4)

mRNA Protein Name
NM_001284297.2 NP_001271226.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2
NM_001284298.2 NP_001271227.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 3
NM_001284299.2 NP_001271228.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 4
NM_004573.3 NP_004564.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1

PLCB2 Protein Structure

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (220 - 310)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (314 - 464)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (545 - 662)

C2

C2: C2 domain (684 - 761)

PLC-beta_C

PLC-beta_C: PLC-beta C terminal (979 - 1155)

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  • 1185 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

phosphoinositide phospholipase C-beta-2

Related Diseases

Diseases Alias
Prostate Leiomyosarcoma

Leiomyosarcoma Of The Prostate
Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h

CSNB1H

Congenital Stationary Night Blindness Type 1h

Night Blindness, Congenital Stationary, 1h
Neurogenic Bowel
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10653 PLCB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLCB2 MGD MGI:107465
Rattus norvegicus PLCB2 RGD RGD:621004
Canis familiaris PLCB2 VGNC VGNC:44645
Bos taurus PLCB2 VGNC VGNC:32981
Macaca mulatta PLCB2 VGNC VGNC:76164
Felis catus PLCB2 VGNC VGNC:80881