2. Gene
  3. LRP1B - LDL receptor related protein 1B Gene

LRP1B - LDL receptor related protein 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LRP-1B; LRPDIT; LRP-DIT

Gene ID: 53353 | Gene type: protein coding

About LRP1B

Cytogenetic location: 2q22.1-q22.2 Genomic coordinates (GRCh38): 2:140,231,423-142,131,016 (from NCBI)

This gene has 5 transcripts (splice variants), 233 orthologues, 14 paralogues and is associated with 159 phenotypes. Biased expression in brain (RPKM 3.0), thyroid (RPKM 1.8) and 4 other tissues.

Summary

This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of Cancer. [provided by RefSeq, Jun 2016]

LRP1B Products(1)

mRNA Protein Name
NM_018557.3 NP_061027.2 low-density lipoprotein receptor-related protein 1B precursor

LRP1B Protein Structure

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (32 - 69)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (76 - 113)

EGF_CA

EGF_CA: Calcium-binding EGF domain (155 - 193)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (295 - 335)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (568 - 608)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (611 - 654)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (659 - 703)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (798 - 833)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (845 - 881)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (885 - 922)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (926 - 962)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (965 - 1002)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1005 - 1042)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1052 - 1088)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1095 - 1131)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (1176 - 1212)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1347 - 1387)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1392 - 1434)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1619 - 1658)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (1838 - 1874)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1965 - 2005)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2008 - 2049)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2330 - 2372)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2510 - 2543)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2551 - 2586)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2589 - 2625)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2644 - 2674)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2681 - 2716)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2719 - 2753)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2760 - 2797)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2804 - 2840)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2844 - 2882)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2890 - 2925)

cEGF

cEGF: Complement Clr-like EGF-like (2948 - 2971)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3056 - 3096)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (3277 - 3313)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3315 - 3352)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3356 - 3391)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3395 - 3431)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3435 - 3471)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3474 - 3510)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3514 - 3549)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3552 - 3587)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3592 - 3628)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3631 - 3667)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3674 - 3710)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3761 - 3796)

EGF_CA

EGF_CA: Calcium-binding EGF domain (3844 - 3880)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (4040 - 4080)

EGF

EGF: EGF-like domain (4254 - 4283)

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  • 4000
  • 4599 a.a.
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 1B

LRP-deleted in tumors

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Male Urethral Cancer

Male Urethral Malignant Neoplasm
Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9

EIG9

Epilepsy, Juvenile Myoclonic 6

Idiopathic Generalized Epilepsy 9

Epilepsy, Juvenile Myoclonic, Susceptibility To, 6

Susceptibility To Idiopathic Generalized Epilepsy 9

Juvenile Myoclonic Epilepsy 6

EJM6

Susceptibility To Juvenile Myoclonic Epilepsy 6

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9
Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia

Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

Hypermethioninemia Encephalopathy Due To Adk Deficiency

Mrt8

Mental Retardation, Autosomal Recessive 8, Formerly

Mrt8, Formerly

HMAKD

Mental Retardation, Autosomal Recessive 8
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07796 LRP1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRP1B RGD RGD:1306160
Macaca mulatta LRP1B VGNC VGNC:74443
Mus musculus LRP1B MGD MGI:2151136
Canis familiaris LRP1B VGNC VGNC:42774