SHC3 - SHC adaptor protein 3 Gene

Homo sapiens

Also known as RAI; NSHC; SHCC; N-Shc

Gene ID: 53358 | Gene type: protein coding

About SHC3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:89,005,771-89,178,818 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.7) and 2 other tissues.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC3 Products(1)

mRNA	Protein	Name
NM_016848.6	NP_058544.3	SHC-transforming protein 3

SHC3 Protein Structure

PID

SH2

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

SHC-transforming protein 3

SH2 domain protein C3

Related Diseases

Diseases

Alias

Spinal Cord Ependymoma

Ependymal Neoplasm Of The Spinal Cord	Spinal Ependymoma
Ependymoma Of Spinal Cord

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12858	SHC3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SHC3	VGNC	VGNC:46141
Mus musculus	SHC3	MGD	MGI:106179
Felis catus	SHC3	VGNC	VGNC:97626
Bos taurus	SHC3	VGNC	VGNC:34591
Rattus norvegicus	SHC3	RGD	RGD:69348