2. Gene
  3. GPR84 - G protein-coupled receptor 84 Gene

GPR84 - G protein-coupled receptor 84 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EX33; GPCR4

Gene ID: 53831 | Gene type: protein coding

About GPR84

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,350,698-54,364,486 (from NCBI)

This gene has 2 transcripts (splice variants), 124 orthologues and 25 paralogues. Biased expression in bone marrow (RPKM 5.7), appendix (RPKM 3.3) and 6 other tissues.

Summary

Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR84 Products(3)

mRNA Protein Name
XM_011538495.3 XP_011536797.1 G-protein coupled receptor 84 isoform X1
XM_047429017.1 XP_047284973.1 G-protein coupled receptor 84 isoform X2
NM_020370.3 NP_065103.1 G-protein coupled receptor 84

GPR84 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (37 - 370)

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  • 396 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 84

inflammation-related G protein-coupled receptor EX33

Related Diseases

Diseases Alias
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-100775 Fezagepras sodium Antagonist 99.65% Phase 3
HY-135303 GLPG1205 Antagonist 99.64% Phase 2
HY-100775A Fezagepras Antagonist / Phase 2
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12764 6-OAU Agonist 99.91% Unkown
HY-112562 GPR84 antagonist 8 Antagonist 99.85% Unkown
HY-124571 ZQ-16 Agonist 99.88% Unkown
HY-139675 GPR84 antagonist 1 Antagonist 99.21% Unkown
HY-145697 GPR84 antagonist 2 Antagonist 99.53% Unkown
HY-151100 GPR84 antagonist 3 Antagonist 99.54% Unkown
HY-163350 TUG-2208 Agonist 98.09% Unkown
HY-161106 OX04528 Agonist 99.71% Unkown
HY-126346 DL-175 Agonist / Unkown
HY-163349 TUG-2099 Inhibitor / Unkown
HY-W182770 GPR84 agonist-1 Agonist / Unkown
HY-161107 OX04529 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR84 VGNC VGNC:67444
Macaca mulatta GPR84 VGNC VGNC:73146
Canis familiaris GPR84 VGNC VGNC:41446
Mus musculus GPR84 MGD MGI:1934129
Bos taurus GPR84 VGNC VGNC:29601
Rattus norvegicus GPR84 RGD RGD:1585277