GPR88 - G protein-coupled receptor 88 Gene

Homo sapiens

Also known as STRG; COCPMR

Gene ID: 54112 | Gene type: protein coding

About GPR88

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,538,139-100,542,021 (from NCBI)

This gene has 1 transcript (splice variant), 147 orthologues, 33 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 5.3), liver (RPKM 2.4) and 4 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

GPR88 Products(1)

mRNA	Protein	Name
NM_022049.3	NP_071332.2	probable G-protein coupled receptor 88

GPR88 Protein Structure

7tm_1

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

probable G-protein coupled receptor 88

striatum-specific G-protein coupled receptor

Related Diseases

Diseases

Alias

Choreatic Disease

Chorea

Hereditary Chorea

Chorea, Childhood-Onset, With Psychomotor Retardation

COCPMR

Chorea

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Dyskinetic Cerebral Palsy

Athetoid Cerebral Palsy	Athetoid Dyskinetic Cerebral Palsy
Cerebral Palsy Athetoid	Cerebral Palsy Dyskinetic
Athetoid Cerebral Paralysis	Dyskinetic Cerebral Paralysis
Vogt Disease	Athetoid Cerebrum Palsy
Double Athetosis Syndrome	État Marbré

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100013A1	(1R,2R)-2-PCCA hydrochloride		98.08%	Unkown
HY-100013C	2-PCCA hydrochloride		99.63%	Unkown
HY-112612A	RTI-13951-33 hydrochloride		98.56%	Unkown
HY-156771	GPR88-IN-1	Inhibitor	99.54%	Unkown
HY-112612	RTI-13951-33		/	Unkown
HY-156772	GPR88 agonist 2	Agonist	99.57%	Unkown
HY-163096	GPR88 agonist 3	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPR88	MGD	MGI:1927653
Canis familiaris	GPR88	VGNC	VGNC:54029
Rattus norvegicus	GPR88	RGD	RGD:61921
Bos taurus	GPR88	VGNC	VGNC:29604
Others	GPR88	NCBI

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