KCNK10 - potassium two pore domain channel subfamily K member 10 Gene

Homo sapiens

Also known as TREK2; TREK-2; K2p10.1; PPP1R97

Gene ID: 54207 | Gene type: protein coding

About KCNK10

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:88,180,108-88,326,912 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 14 paralogues. Biased expression in brain (RPKM 1.7), duodenum (RPKM 1.4) and 8 other tissues.

Summary

The protein encoded by this gene belongs to the family of Potassium Channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

KCNK10 Products(3)

mRNA	Protein	Name
NM_021161.5	NP_066984.1	potassium channel subfamily K member 10 isoform 1 precursor
NM_138317.3	NP_612190.1	potassium channel subfamily K member 10 isoform 2
NM_138318.3	NP_612191.1	potassium channel subfamily K member 10 isoform 3

KCNK10 Protein Structure

Ion_trans_2

0
100
200
300
400
500
538 a.a.

Protein Preferred Names

Protein Names

potassium channel subfamily K member 10

2P domain potassium channel TREK2

Related Diseases

Diseases

Alias

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Brain Glioblastoma Multiforme

Brain Glioblastoma	Glioblastoma Multiforme Of Brain
Glioblastoma Nos

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07153	KCNK10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KCNK10	VGNC	VGNC:73994
Felis catus	KCNK10	VGNC	VGNC:67919
Mus musculus	KCNK10	MGD	MGI:1919508
Canis familiaris	KCNK10	VGNC	VGNC:42270
Bos taurus	KCNK10	VGNC	VGNC:30466
Rattus norvegicus	KCNK10	RGD	RGD:619732

Name
Email *

	Sorry, but the email address you supplied was invalid.