2. Gene
  3. POLR2B - RNA polymerase II subunit B Gene

POLR2B - RNA polymerase II subunit B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RPB2; POL2RB; hRPB140

Gene ID: 5431 | Gene type: protein coding

About POLR2B

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,978,896-57,031,158 (from NCBI)

This gene has 12 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 28.6), testis (RPKM 28.1) and 25 other tissues.

Summary

This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and MicroRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the FLAP loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

POLR2B Products(3)

mRNA Protein Name
NM_000938.3 NP_000929.1 DNA-directed RNA polymerase II subunit RPB2 isoform 1
NM_001303268.2 NP_001290197.1 DNA-directed RNA polymerase II subunit RPB2 isoform 2
NM_001303269.2 NP_001290198.1 DNA-directed RNA polymerase II subunit RPB2 isoform 3

POLR2B Protein Structure

RNA_pol_Rpb2_1

RNA_pol_Rpb2_1: RNA polymerase beta subunit (38 - 451)

RNA_pol_Rpb2_2

RNA_pol_Rpb2_2: RNA polymerase Rpb2, domain 2 (201 - 394)

RNA_pol_Rpb2_3

RNA_pol_Rpb2_3: RNA polymerase Rpb2, domain 3 (468 - 533)

RNA_pol_Rpb2_4

RNA_pol_Rpb2_4: RNA polymerase Rpb2, domain 4 (567 - 629)

RNA_pol_Rpb2_5

RNA_pol_Rpb2_5: RNA polymerase Rpb2, domain 5 (653 - 700)

RNA_pol_Rpb2_6

RNA_pol_Rpb2_6: RNA polymerase Rpb2, domain 6 (706 - 1080)

RNA_pol_Rpb2_7

RNA_pol_Rpb2_7: RNA polymerase Rpb2, domain 7 (1082 - 1172)

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  • 1174 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB2

DNA-directed RNA polymerase II 140 kDa polypeptide

Related Diseases

Diseases Alias
Fusariosis

Fusarium Infection
Eumycotic Mycetoma

Eumycetoma

Maduromycosis

Mycetoma

Madura Foot

Maduromycosis, Mycotic

Mycotic Mycetoma

Mycetoma Of Foot

Eumycotic Maduromycosis

Mycetoma Due To Fungal Infection
Dermatomycosis

Dermatomycoses
Basidiobolomycosis

Infection By Basidiobolus

Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum
White Piedra

Tinea Blanca

Trichosporosis Nodosa
Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia
Phaeohyphomycosis

Infection By Dematiacious Fungi

Phaehyphomycosis

Phaeomycosis

Pheohyphomycosis

Infection By Dematiacious Fungi [Phaehyphomycosis]

Dematiaceous Fungal Infection
Tinea Nigra

Microsporosis Nigra

Infection By Cladosporium Werneckii

Keratomycosis Nigricans

Tinea Palmaris Nigra

Keratomycosis Nigricans Palmaris
Otomycosis

Singapore Ear
Trichosporonosis
Adiaspiromycosis
Diamond-Blackfan Anemia 5

DBA5

Rpl35a-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 5
External Ear Disease

Diseases Of External Ear

Preauricular Cyst

Preauricular Sinus And Fistula

Preauricular Sinus Or Fistula
Esophageal Atresia/Tracheoesophageal Fistula

Esophageal Atresia And/Or Tracheoesophageal Fistula

Tracheoesophageal Fistula With Or Without Esohageal Atresia

Esophageal Atresia / Tracheoesophageal Fistula

Ea/Tef

Esophageal Atresia With Tracheoesophageal Fistula

Esophageal Atresia With Or Without Tracheoesophageal Fistula
Otitis Externa

Swimmer'S Ear

Infective Otitis Externa

Acute Infective Otitis Externa
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection
Actinomycosis

Actinomycetoma

Boil

Canaliculitis

Actinomycotic Infection

Actinomycotic Madura Foot

Keratoactinomycosis

Furuncle

Actinomycotic Mycetema

Actinomycotic Mycetoma Of Foot

Madura Foot Due To Actinomadura

Actinomyces Israeli

Actinomycetes

Anaerobic Actinomyces Infection

Actinomycotic Infection Of Unspecified Site

Actinomycosis Nos

Actinomycotic Node

Actinomyces Infection

Actinomycotic Mycetoma

Mycetoma Due To Filamentous Bacteria
Sick Building Syndrome
Superficial Keratitis
Subcutaneous Mycosis

Subcutaneous Fungal Disease
Tinea Capitis

Dermatophytosis Of Scalp

Scalp Ringworm

Dermatophytosis Of Scalp Or Beard

Tinea Capitis Due To Trichophyton Rubrum

Trichophyton Rubrum Tinea Capitis
Fungal Infectious Disease

Mycoses

Mycosis
Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin
Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10843 POLR2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta POLR2B VGNC VGNC:76211
Rattus norvegicus POLR2B RGD RGD:1309477
Canis familiaris POLR2B VGNC VGNC:44793
Mus musculus POLR2B MGD MGI:2388280
Bos taurus POLR2B VGNC VGNC:33136
Felis catus POLR2B VGNC VGNC:68947