POLR2E - RNA polymerase II, I and III subunit E Gene

Homo sapiens

Also known as RPB5; XAP4; RPABC1; hRPB25; hsRPB5

Gene ID: 5434 | Gene type: protein coding

About POLR2E

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,086,574-1,095,375 (from NCBI)

This gene has 14 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in fat (RPKM 46.7), kidney (RPKM 21.6) and 25 other tissues.

Summary

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

POLR2E Products(3)

mRNA	Protein	Name
NM_001316323.2	NP_001303252.1	DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform b
NM_001316324.2	NP_001303253.1	DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform b
NM_002695.5	NP_002686.3	DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform a

POLR2E Protein Structure

RNA_pol_Rpb5_N

RNA_pol_Rpb5_C

0
100
210 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerases I, II, and III subunit RPABC1

DNA directed RNA polymerase II 23 kda polypeptide

Related Diseases

Diseases

Alias

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10846	POLR2E Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	POLR2E	VGNC	VGNC:44796
Macaca mulatta	POLR2E	VGNC	VGNC:76214
Rattus norvegicus	POLR2E	RGD	RGD:1589817
Mus musculus	POLR2E	MGD	MGI:1913670
Bos taurus	POLR2E	VGNC	VGNC:33139
Felis catus	POLR2E	VGNC	VGNC:68950

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