POLR2L - RNA polymerase II, I and III subunit L Gene

Homo sapiens

Also known as RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; RPB10beta

Gene ID: 5441 | Gene type: protein coding

About POLR2L

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:839,721-842,529 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 85.5), kidney (RPKM 42.9) and 25 other tissues.

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

POLR2L Products(1)

mRNA	Protein	Name
NM_021128.5	NP_066951.1	DNA-directed RNA polymerases I, II, and III subunit RPABC5

POLR2L Protein Structure

RNA_pol_N

0
67 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerases I, II, and III subunit RPABC5

DNA-directed RNA polymerase III subunit L

Related Diseases

Diseases

Alias

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Hyperparathyroidism 2 With Jaw Tumors

Hyperparathyroidism-Jaw Tumor Syndrome	Hpt-Jt
HRPT2	Familial Primary Hyperparathyroidism With Multiple Ossifying Jaw Fibromas
Parathyroid Adenoma With Cystic Changes	Hereditary Hyperparathyroidism-Jaw Tumor Syndrome
Hyperparathyroidism 2	Hyperparathyroidism, Familial Primary, With Multiple Ossifying Jaw Fibromas
Hyperparathyroidism-Jaw Tumor Syndrome, Hereditary	Familial Cystic Parathyroid Adenomatosis
Hyperparathyroidism-Jaw Tumor Syndrome, Type 2	Parathyroid Adenomatosis, Familial Cystic

Hepatitis D

Delta Hepatitis	Hepatitis Delta
Hdv	Hepatitis D Virus
Hepatitis D Infection

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Rapp-Hodgkin Syndrome

RHS	Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate
Ectodermal Dysplasia, Rapp-Hodgkin Type	Rapp-Hodgkin Ectodermal Dysplasia Syndrome
Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate	Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type
Edrh	Rapp-Hodgkin Ectodermal Dysplasia
Orofacial Cleft 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10854	POLR2L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	POLR2L	MGD	MGI:1913741
Rattus norvegicus	POLR2L	RGD	RGD:1566209
Felis catus	POLR2L	VGNC	VGNC:105827
Bos taurus	POLR2L	VGNC	VGNC:33144

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