SSH1 - slingshot protein phosphatase 1 Gene

Homo sapiens

Also known as SSH1L

Gene ID: 54434 | Gene type: protein coding

About SSH1

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,778,191-108,857,583 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 30 paralogues. Ubiquitous expression in gall bladder (RPKM 6.2), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

SSH1 Products(3)

mRNA	Protein	Name
NM_001161330.2	NP_001154802.1	protein phosphatase Slingshot homolog 1 isoform 2
NM_001161331.1	NP_001154803.1	protein phosphatase Slingshot homolog 1 isoform 3
NM_018984.4	NP_061857.3	protein phosphatase Slingshot homolog 1 isoform 1

SSH1 Protein Structure

DEK_C

DSPc

0
200
400
600
800
1049 a.a.

Protein Preferred Names

Protein Names

protein phosphatase Slingshot homolog 1

SSH-like protein 1

Related Diseases

Diseases

Alias

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Marginal Corneal Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13809	SSH1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSH1	VGNC	VGNC:46831
Macaca mulatta	SSH1	VGNC	VGNC:78017
Rattus norvegicus	SSH1	RGD	RGD:1306038
Bos taurus	SSH1	VGNC	VGNC:35312
Mus musculus	SSH1	MGD	MGI:2686240
Felis catus	SSH1	VGNC	VGNC:65703