RNF186 - ring finger protein 186 Gene

Homo sapiens

Gene ID: 54546 | Gene type: protein coding

About RNF186

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,814,029-19,815,283 (from NCBI)

This gene has 1 transcript (splice variant) and 87 orthologues.

Summary

Enables ubiquitin-protein transferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF186 Products(1)

mRNA	Protein	Name
NM_019062.2	NP_061935.1	E3 ubiquitin-protein ligase RNF186

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF186

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 9

IBD9

Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma	Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type
Finkel Disease	Smafk
Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant	Autosomal Dominant Adult Proximal Spinal Muscular Atrophy
Finkel Late-Adult Type Sma

Immunodeficiency 60

Bach2-Related Immunodeficiency And Autoimmunity	Brida
Imd60

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12070	RNF186 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF186	MGD	MGI:1914075
Rattus norvegicus	RNF186	RGD	RGD:1596075
Canis familiaris	RNF186	VGNC	VGNC:45649
Bos taurus	RNF186	VGNC	VGNC:34043

Name
Email *

	Sorry, but the email address you supplied was invalid.