PAF1 - PAF1 homolog, Paf1/RNA polymerase II complex component Gene

Homo sapiens

Also known as PD2; F23149_1

Gene ID: 54623 | Gene type: protein coding

About PAF1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,385,629-39,391,106 (from NCBI)

This gene has 8 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in testis (RPKM 32.1), ovary (RPKM 17.7) and 25 other tissues.

Summary

This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

PAF1 Products(2)

mRNA	Protein	Name
NM_001256826.2	NP_001243755.1	RNA polymerase II-associated factor 1 homolog isoform 2
NM_019088.4	NP_061961.2	RNA polymerase II-associated factor 1 homolog isoform 1

PAF1 Protein Structure

Paf1

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

RNA polymerase II-associated factor 1 homolog

Paf1, RNA polymerase II associated factor, homolog

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 3

DBA3	Anemia, Diamond-Blackfan, 3
Rps24-Related Diamond-Blackfan Anemia	Anemia Diamond-Blackfan 3
Anemia, Diamond-Blackfan, Type 3

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Otopalatodigital Syndrome, Type Ii

Otopalatodigital Syndrome Type 2	Faciopalatoosseous Syndrome
OPD2	Opd Ii Syndrome
Opd Syndrome 2	Cranioorodigital Syndrome
Fpo	Oto-Palato-Digital Syndrome, Type Ii
Andre Syndrome	Oto-Palato-Digital Syndrome Type 2
Otopalatodigital Syndrome Type Ii	Cranio-Oro-Digital Syndrome
Opd 2 Syndrome	Opd Syndrome, Type 2
Taybi Syndrome	Otopalatodigital Syndrome 2
Oto-Palato-Digital Syndrome, Type 2	Oto-Palato-Digital Syndrome Type 1

Retinitis Pigmentosa 40

RP40	Retinitis Pigmentosa-40
Retinitis Pigmentosa, Type 40

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Myopathy, Distal, 4

Distal Myopathy With Posterior Leg And Anterior Hand Involvement	MPD4
Williams Distal Myopathy	Distal Muscular Dystrophy 4
Distal Abd-Filaminopathy	Distal Myopathy 4
Myopathy, Distal, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3103A	PINT-87aa TFA		≥99.0%	Unkown
HY-130345S	C18-PAF-d4		/	Unkown
HY-160267	iPAF1C	Inhibitor	/	Unkown
HY-N2247A	(+)-Guaiacin		/	Unkown
HY-P3103	PINT-87aa		/	Unkown
HY-RS09966	PAF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PAF1	RGD	RGD:1306219
Mus musculus	PAF1	MGD	MGI:1923988
Felis catus	PAF1	VGNC	VGNC:64024
Bos taurus	PAF1	VGNC	VGNC:96701
Macaca mulatta	PAF1	VGNC	VGNC:81492
Others	PAF1	NCBI

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