2. Gene
  3. RNF111 - ring finger protein 111 Gene

RNF111 - ring finger protein 111 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARK; hRNF111

Gene ID: 54778 | Gene type: protein coding

About RNF111

Cytogenetic location: 15q22.1-q22.2 Genomic coordinates (GRCh38): 15:58,987,663-59,097,419 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 5.8), brain (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

RNF111 Products(5)

mRNA Protein Name
NM_001270528.2 NP_001257457.1 E3 ubiquitin-protein ligase Arkadia isoform 1
NM_001270529.2 NP_001257458.1 E3 ubiquitin-protein ligase Arkadia isoform 3
NM_001270530.2 NP_001257459.1 E3 ubiquitin-protein ligase Arkadia isoform 4
NM_001330331.2 NP_001317260.1 E3 ubiquitin-protein ligase Arkadia isoform 5
NM_017610.8 NP_060080.6 E3 ubiquitin-protein ligase Arkadia isoform 2

RNF111 Protein Structure

RNF111_N

RNF111_N: E3 ubiquitin-protein ligase Arkadia N-terminus (18 - 292)

zf-RING_2

zf-RING_2: Ring finger domain (941 - 983)

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  • 994 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Arkadia

Arkadia

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12036 RNF111 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF111 RGD RGD:1310097
Macaca mulatta RNF111 VGNC VGNC:76751
Mus musculus RNF111 MGD MGI:1934919
Canis familiaris RNF111 VGNC VGNC:45621
Felis catus RNF111 VGNC VGNC:64663
Bos taurus RNF111 VGNC VGNC:34010