2. Gene
  3. DNAJB12 - DnaJ heat shock protein family (Hsp40) member B12 Gene

DNAJB12 - DnaJ heat shock protein family (Hsp40) member B12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DJ10

Gene ID: 54788 | Gene type: protein coding

About DNAJB12

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,332,863-72,354,919 (from NCBI)

This gene has 6 transcripts (splice variants), 283 orthologues and 11 paralogues. Ubiquitous expression in testis (RPKM 9.5), kidney (RPKM 9.2) and 25 other tissues.

Summary

DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

DNAJB12 Products(4)

mRNA Protein Name
NM_001002762.5 NP_001002762.3 dnaJ homolog subfamily B member 12 isoform 1
NM_001365080.3 NP_001352009.1 dnaJ homolog subfamily B member 12 isoform 2
NM_001365081.3 NP_001352010.1 dnaJ homolog subfamily B member 12 isoform 1
NM_017626.7 NP_060096.4 dnaJ homolog subfamily B member 12 isoform 1

DNAJB12 Protein Structure

DnaJ

DnaJ: DnaJ domain (144 - 205)

DUF1977

DUF1977: Domain of unknown function (DUF1977) (296 - 402)

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  • 300
  • 409 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily B member 12

DnaJ (Hsp40) homolog, subfamily B, member 12

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C2

NPC2

Niemann-Pick Disease Type C2

Niemann-Pick C2 Disease

Niemann-Pick Disease C2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03865 DNAJB12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DNAJB12 MGD MGI:1931881
Rattus norvegicus DNAJB12 RGD RGD:1359677
Bos taurus DNAJB12 VGNC VGNC:55983
Macaca mulatta DNAJB12 VGNC VGNC:106032