2. Gene
  3. FNBP1L - formin binding protein 1 like Gene

FNBP1L - formin binding protein 1 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TOCA1; C1orf39

Gene ID: 54874 | Gene type: protein coding

About FNBP1L

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,448,118-93,554,661 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 14.8), kidney (RPKM 13.9) and 24 other tissues.

Summary

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin Cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FNBP1L Products(3)

mRNA Protein Name
NM_001024948.3 NP_001020119.1 formin-binding protein 1-like isoform 1
NM_001164473.3 NP_001157945.1 formin-binding protein 1-like isoform 3
NM_017737.5 NP_060207.2 formin-binding protein 1-like isoform 2

FNBP1L Protein Structure

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (1 - 93)

SH3_1

SH3_1: SH3 domain (544 - 591)

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  • 605 a.a.
Protein Preferred Names Protein Names

formin-binding protein 1-like

toca-1

Related Diseases

Diseases Alias
Alzheimer Disease 11

Ad11

Alzheimer'S Disease 11

Alzheimer Disease, Familial, 11

Alzheimer Disease-11

Alzheimer'S Disease 11, Late Onset
Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma
Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05017 FNBP1L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FNBP1L MGD MGI:1925642
Canis familiaris FNBP1L VGNC VGNC:40925
Bos taurus FNBP1L VGNC VGNC:29060
Rattus norvegicus FNBP1L RGD RGD:1305386
Macaca mulatta FNBP1L VGNC VGNC:72543
Felis catus FNBP1L VGNC VGNC:62317