BCOR - BCL6 corepressor Gene

Homo sapiens

Also known as MAA2; ANOP2; MCOPS2

Gene ID: 54880 | Gene type: protein coding

About BCOR

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:40,051,246-40,177,329 (from NCBI)

This gene has 17 transcripts (splice variants), 249 orthologues, 1 paralogue and is associated with 156 phenotypes. Ubiquitous expression in thyroid (RPKM 8.0), lymph node (RPKM 7.0) and 25 other tissues.

Summary

The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence Apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

BCOR Products(4)

mRNA	Protein	Name
NM_001123383.1	NP_001116855.1	BCL-6 corepressor isoform a
NM_001123384.2	NP_001116856.1	BCL-6 corepressor isoform b
NM_001123385.2	NP_001116857.1	BCL-6 corepressor isoform c
NM_017745.6	NP_060215.4	BCL-6 corepressor isoform a

BCOR Protein Structure

Ank_2

0
300
600
900
1200
1500
1755 a.a.

Protein Preferred Names

Protein Names

BCL-6 corepressor

BCL-6 coreceptor

Related Diseases

Diseases

Alias

Microphthalmia, Syndromic 2

Oculofaciocardiodental Syndrome	Ofcd Syndrome
MCOPS2	Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects
Syndromic Microphthalmia 2	Anop2
Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome	Maa2
Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects	Syndromic Microphthalmia Type 2
Oculo-Facio-Cardio-Dental Syndrome	Anop2, Formerly
Maa2, Formerly	Microphthalmia Syndromic 2
Oculo Facio Cardio Dental Syndrome	Microphthalmia, Syndromic, 2
Marashi-Gorlin Syndrome	Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects
Microphthalmia, Syndromic, Type 2

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Adenoid Cystic Carcinoma

Adenocystic Carcinoma	Cribriform Carcinoma
Cylindroma	Carcinoma Adenoid Cystic
Carcinoma, Adenoid Cystic	Adenoid Cystic Carcinoma Of Salivary Gland
Eccrine Dermal Cylindroma	Carcinoma, Cribriform

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Syndromic Microphthalmia

Microphthalmia, Syndromic

Ventricular Septal Defect

Ventricular Septal Defects	Interventricular Septal Defect
Heart Septal Defects, Ventricular	Ventricular Septal Abnormality
Interventricular Septum Defect	Ventricular Septum Defect
Vsd - [Ventricular Septum Defect]	Congenital Ventricular Septal Defect
Single Ventricular Septal Defect

Adenosarcoma

Mullerian Adenosarcoma

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Hypertrichosis

Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01448	BCOR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BCOR	VGNC	VGNC:97366
Mus musculus	BCOR	MGD	MGI:1918708
Macaca mulatta	BCOR	VGNC	VGNC:97738
Rattus norvegicus	BCOR	RGD	RGD:1562735
Canis familiaris	BCOR	VGNC	VGNC:53706
Bos taurus	BCOR	VGNC	VGNC:56520