2. Gene
  3. KANSL2 - KAT8 regulatory NSL complex subunit 2 Gene

KANSL2 - KAT8 regulatory NSL complex subunit 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NSL2; C12orf41

Gene ID: 54934 | Gene type: protein coding

About KANSL2

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:48,653,211-48,682,238 (from NCBI)

This gene has 15 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in bone marrow (RPKM 25.9), testis (RPKM 12.9) and 25 other tissues.

Summary

Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

KANSL2 Products(1)

mRNA Protein Name
NM_017822.4 NP_060292.3 KAT8 regulatory NSL complex subunit 2

KANSL2 Protein Structure

zf-C3Hc3H

zf-C3Hc3H: Potential DNA-binding domain (28 - 92)

zf-C3Hc3H

zf-C3Hc3H: Potential DNA-binding domain (302 - 365)

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  • 492 a.a.
Protein Preferred Names Protein Names

KAT8 regulatory NSL complex subunit 2

NSL complex protein NSL2

Related Diseases

Diseases Alias
Koolen-De Vries Syndrome

KDVS

17q21.31 Microdeletion Syndrome

Microdeletion 17q21.31 Syndrome

Chromosome 17q21.31 Deletion Syndrome

Koolen De Vries Syndrome

Kansl1-Related Intellectual Disability Syndrome

Chromosome 17q21.31 Microdeletion Syndrome

Monosomy 17q21.31

17q21.31 Deletion Syndrome

Koolen Syndrome

Del(17)(Q21.31)
Heinz Body Anemias

Heinz Body Anemia

Heinz Body Anemias, Alpha-

HEIBAN

Anemia, Heinz Body

Acquired Heinz Body Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07068 KANSL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KANSL2 VGNC VGNC:73910
Bos taurus KANSL2 VGNC VGNC:30394
Rattus norvegicus KANSL2 RGD RGD:1303127
Canis familiaris KANSL2 VGNC VGNC:42205
Felis catus KANSL2 VGNC VGNC:63020
Mus musculus KANSL2 MGD MGI:1916862