2. Gene
  3. LPCAT2 - lysophosphatidylcholine acyltransferase 2 Gene

LPCAT2 - lysophosphatidylcholine acyltransferase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AYTL1; LPLAT9; AGPAT11; LysoPAFAT

Gene ID: 54947 | Gene type: protein coding

About LPCAT2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,509,072-55,586,666 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues.

Summary

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded Enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The Enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

LPCAT2 Products(1)

mRNA Protein Name
NM_017839.5 NP_060309.2 lysophosphatidylcholine acyltransferase 2

LPCAT2 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (129 - 245)

EF-hand_7

EF-hand_7: EF-hand domain pair (396 - 456)

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  • 544 a.a.
Protein Preferred Names Protein Names

lysophosphatidylcholine acyltransferase 2

1-AGP acyltransferase 11

Related Diseases

Diseases Alias
Multicentric Osteolysis, Nodulosis, And Arthropathy

Torg-Winchester Syndrome

Torg Syndrome

Nao Syndrome

MONA

Nodulosis-Arthropathy-Osteolysis Syndrome

Al-Aqeel Sewairi Syndrome

Hereditary Multicentric Osteolysis

Osteolysis, Hereditary Multicentric

Torg-Winchester Syndrome, Formerly

Multicentric Osteolysis Nodulosis And Arthropathy

Multicentric Osteolysis, Nodulosis And Arthropathy

Osteolysis, Multicentric, Nodulosis, And Arthropathy
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Scrotal Carcinoma

Carcinoma Of Scrotum

Malignant Neoplasm Of Scrotum

Neoplasm Of Scrotum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07765 LPCAT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LPCAT2 RGD RGD:2325051
Bos taurus LPCAT2 VGNC VGNC:30962
Macaca mulatta LPCAT2 VGNC VGNC:74365
Felis catus LPCAT2 VGNC VGNC:63265
Canis familiaris LPCAT2 VGNC VGNC:42749
Mus musculus LPCAT2 MGD MGI:3606214