HPF1 - histone PARylation factor 1 Gene

Homo sapiens

Also known as C4orf27

Gene ID: 54969 | Gene type: protein coding

About HPF1

Cytogenetic location: 4q33 Genomic coordinates (GRCh38): 4:169,729,470-169,757,944 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 6.3), endometrium (RPKM 6.0) and 25 other tissues.

Summary

Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

HPF1 Products(1)

mRNA	Protein	Name
NM_017867.3	NP_060337.2	histone PARylation factor 1

HPF1 Protein Structure

DUF2228

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

histone PARylation factor 1

UPF0609 protein C4orf27

Related Diseases

Diseases

Alias

Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06337	HPF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HPF1	MGD	MGI:1919862
Bos taurus	HPF1	VGNC	VGNC:56972
Macaca mulatta	HPF1	VGNC	VGNC:100235
Rattus norvegicus	HPF1	RGD	RGD:1311747
Canis familiaris	HPF1	VGNC	VGNC:50635
Felis catus	HPF1	VGNC	VGNC:78510

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