PINX1 - PIN2 (TERF1) interacting telomerase inhibitor 1 Gene

Homo sapiens

Also known as Gno1; LPTL; LPTS; Pxr1

Gene ID: 54984 | Gene type: protein coding

About PINX1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,764,961-10,839,875 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 5.1), appendix (RPKM 4.5) and 25 other tissues.

Summary

Enables Telomerase RNA binding activity and Telomerase Inhibitor activity. Involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via Telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

PINX1 Products(2)

mRNA	Protein	Name
NM_001284356.2	NP_001271285.1	PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
NM_017884.6	NP_060354.4	PIN2/TERF1-interacting telomerase inhibitor 1 isoform 1

PINX1 Protein Structure

G-patch

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

PIN2/TERF1-interacting telomerase inhibitor 1

67-11-3 protein

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 22

IBD22

Thrombophlebitis Migrans

Ulcerative Stomatitis

Stomatitis Ulcerative	Aphthous Stomatitis
Minor Oral Aphthous Ulceration

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10560	PINX1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PINX1	VGNC	VGNC:79362
Mus musculus	PINX1	MGD	MGI:1919650
Rattus norvegicus	PINX1	RGD	RGD:1566025
Bos taurus	PINX1	VGNC	VGNC:32905
Canis familiaris	PINX1	VGNC	VGNC:44569

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