2. Gene
  3. ENOX1 - ecto-NOX disulfide-thiol exchanger 1 Gene

ENOX1 - ecto-NOX disulfide-thiol exchanger 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CNOX; PIG38; cCNOX; bA64J21.1

Gene ID: 55068 | Gene type: protein coding

About ENOX1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:43,213,130-43,786,972 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.9), brain (RPKM 1.3) and 19 other tissues.

Summary

The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]

ENOX1 Products(12)

mRNA Protein Name
NM_001127615.3 NP_001121087.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001242863.3 NP_001229792.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347963.2 NP_001334892.1 ecto-NOX disulfide-thiol exchanger 1 isoform a
NM_001347964.2 NP_001334893.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347965.2 NP_001334894.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347966.2 NP_001334895.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347967.2 NP_001334896.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347968.2 NP_001334897.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347969.2 NP_001334898.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347970.2 NP_001334899.1 ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_001347971.2 NP_001334900.1 ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_017993.5 NP_060463.2 ecto-NOX disulfide-thiol exchanger 1 isoform b

ENOX1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (144 - 199)

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  • 643 a.a.
Protein Preferred Names Protein Names

ecto-NOX disulfide-thiol exchanger 1

candidate growth-related and time keeping constitutive hydroquinone (NADH) oxidase

Related Diseases

Diseases Alias
Hypocalcemia, Autosomal Dominant 2

Autosomal Dominant Hypocalcemia 2

HYPOC2

Hypocalcemia, Autosomal Dominant, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04384 ENOX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ENOX1 VGNC VGNC:40371
Mus musculus ENOX1 MGD MGI:2444896
Bos taurus ENOX1 VGNC VGNC:28502
Macaca mulatta ENOX1 VGNC VGNC:72110
Felis catus ENOX1 VGNC VGNC:61869
Rattus norvegicus ENOX1 RGD RGD:1306118