DET1 - DET1 partner of COP1 E3 ubiquitin ligase Gene

Homo sapiens

Gene ID: 55070 | Gene type: protein coding

About DET1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,501,919-88,546,703 (from NCBI)

This gene has 8 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.7) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DET1 Products(4)

mRNA	Protein	Name
NM_001144074.3	NP_001137546.1	DET1 homolog isoform 2
NM_001321594.2	NP_001308523.1	DET1 homolog isoform 3
NM_001321596.1	NP_001308525.1	DET1 homolog isoform 2
NM_017996.5	NP_060466.2	DET1 homolog isoform 1

DET1 Protein Structure

Det1

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550 a.a.

Protein Preferred Names

Protein Names

DET1 homolog

DET1, COP1 ubiquitin ligase partner

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03706	DET1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DET1	VGNC	VGNC:49598
Rattus norvegicus	DET1	RGD	RGD:1309793
Mus musculus	DET1	MGD	MGI:1923625
Macaca mulatta	DET1	VGNC	VGNC:99197
Felis catus	DET1	VGNC	VGNC:80989
Bos taurus	DET1	VGNC	VGNC:49548

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