PPP2R5B - protein phosphatase 2 regulatory subunit B'beta Gene

Homo sapiens

Also known as B56B; PR61B; B56beta

Gene ID: 5526 | Gene type: protein coding

About PPP2R5B

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,917,573-64,934,475 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 15.1), gall bladder (RPKM 6.6) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

PPP2R5B Products(1)

mRNA	Protein	Name
NM_006244.4	NP_006235.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

PPP2R5B Protein Structure

B56

0
100
200
300
400
497 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

protein phosphatase 2 regulatory subunit B', beta

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 30

Spinocerebellar Ataxia Type 30	SCA30
Cerebellar Ataxia Early-Onset Nonprogressive	Spinocerebellar Ataxia 29
Acv	Aplasia Of Cerebellar Vermis
Cerebellar Vermis Aplasia	Congenital Nonprogressive Spinocerebellar Ataxia
Sca29	Spinocerebellar Ataxia Type 29

Spinocerebellar Ataxia 25

Spinocerebellar Ataxia Type 25

SCA25

Spinocerebellar Ataxia 21

Spinocerebellar Ataxia Type 21	SCA21
Ataxia, Spinocerebellar, Type 21

Spinocerebellar Ataxia 20

Spinocerebellar Ataxia Type 20	SCA20
Spinocerebellar Ataxia With Dysphonia	Spinocerebellar Ataxia With Spasmodic Cough
Chromosome 11q12 Duplication Syndrome, 260-Kb	Chromosome 11q12 Duplication Syndrome 260-Kb

Spinocerebellar Ataxia 12

Spinocerebellar Ataxia Type 12	SCA12
Ataxia, Spinocerebellar, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11019	PPP2R5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP2R5B	VGNC	VGNC:69016
Bos taurus	PPP2R5B	VGNC	VGNC:33261
Rattus norvegicus	PPP2R5B	RGD	RGD:727786
Mus musculus	PPP2R5B	MGD	MGI:2388480
Macaca mulatta	PPP2R5B	VGNC	VGNC:101383
Canis familiaris	PPP2R5B	VGNC	VGNC:44914

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