NUDT15 - nudix hydrolase 15 Gene

Homo sapiens

Also known as MTH2; NUDT15D

Gene ID: 55270 | Gene type: protein coding

About NUDT15

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,037,726-48,052,755 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 4.7), duodenum (RPKM 4.1) and 25 other tissues.

Summary

This gene encodes an Enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded Enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]

NUDT15 Products(2)

mRNA	Protein	Name
NM_001304745.2	NP_001291674.1	nucleotide triphosphate diphosphatase NUDT15 isoform 2
NM_018283.4	NP_060753.1	nucleotide triphosphate diphosphatase NUDT15 isoform 1

NUDT15 Protein Structure

NUDIX

0
100
164 a.a.

Protein Preferred Names

Protein Names

nucleotide triphosphate diphosphatase NUDT15

8-oxo-dGTPase NUDT15

Related Diseases

Diseases

Alias

Thiopurines, Poor Metabolism Of, 2

THPM2

Nudt15 Deficiency

Leukemia, Acute Lymphoblastic 3

Leukemia, Acute Lymphoblastic, Susceptibility To, 3	ALL3
Precursor B-Cell Acute Lymphoblastic Leukemia	B-All
Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma	Precursor B-Cell Acute Lymphocytic Leukemia
Precursor B-Cell Acute Lymphocytic Leukemia/Lymphoma	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Burkitt Lymphoma	Precursor B-Cell Lymphoblastic Leukemia

Thiopurines, Poor Metabolism Of, 1

Thiopurine S-Methyltransferase Deficiency	Tpmt Deficiency
Thiopurine Methyltransferase Deficiency	Thiopurine S Methyltranferase Deficiency
THPM1	Tpmtd
Poor Metabolism Of Thiopurines-1	6-Mercaptopurine Sensitivity
Thiopurines, Poor Metabolism Of	Poor Metabolism Of Thiopurines

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Alopecia

Liver Rhabdomyosarcoma

Rhabdomyosarcoma Of Liver

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139193	TH1760		/	Unkown
HY-RS09665	NUDT15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NUDT15	MGD	MGI:2443366
Bos taurus	NUDT15	VGNC	VGNC:32329
Macaca mulatta	NUDT15	VGNC	VGNC:106278
Rattus norvegicus	NUDT15	RGD	RGD:1308292
Felis catus	NUDT15	VGNC	VGNC:102274
Canis familiaris	NUDT15	VGNC	VGNC:44027

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