SHFL - shiftless antiviral inhibitor of ribosomal frameshifting Gene

Homo sapiens

Also known as SFL; IRAV; RyDEN; C19orf66

Gene ID: 55337 | Gene type: protein coding

About SHFL

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,086,317-10,093,243 (from NCBI)

This gene has 11 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in liver (RPKM 17.9), spleen (RPKM 17.5) and 25 other tissues.

Summary

This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]

SHFL Products(2)

mRNA	Protein	Name
NM_001308277.2	NP_001295206.1	shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 2
NM_018381.4	NP_060851.2	shiftless antiviral inhibitor of ribosomal frameshifting protein isoform 1

SHFL Protein Structure

UPF0515

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

shiftless antiviral inhibitor of ribosomal frameshifting protein

Repressor of yield of Dengue virus

Related Diseases

Diseases

Alias

Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I	Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome
Hsan1e	Hsan1
Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy	Hsn1e
Hsnie	Hereditary Sensory Neuropathy Type Ie
Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory And Autonomic Neuropathy Type 1e	Hereditary Sensory Neuropathy With Hearing Loss And Dementia
Dnmt1-Complex Disorder	Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss
Hsn Ie	Hereditary Sensory Autonomic Neuropathy, Type 1
Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Neuropathy, Hereditary Sensory, Type Ie

HSN1E	Hsn Ie
Hereditary Sensory Neuropathy Type 1e	Hereditary Sensory Neuropathy Type Ie
Hsan 1	Neuropathy, Hereditary Sensory, With Hearing Loss And Dementia
Hereditary Sensory Neuropathy Type 1	Hsn1
Hereditary Sensory And Autonomic Neuropathy Type 1	Neuropathy Hereditary Sensory And Autonomic Type 1
Neuropathy Hereditary Sensory Radicular, Autosomal Dominant	Neuropathy, Hereditary Sensory, 1e
Neuropathy Hereditary Sensory With Hearing Loss And Dementia	Neuropathy, Hereditary Sensory, Type I
Neuropathy, Sensory, Hereditary, Type Ie	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory Autonomic Neuropathy, Type 1

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12864	SHFL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SHFL	VGNC	VGNC:77311
Bos taurus	SHFL	VGNC	VGNC:55202
Rattus norvegicus	SHFL	RGD	RGD:1565995
Mus musculus	SHFL	MGD	MGI:2441788
Canis familiaris	SHFL	VGNC	VGNC:52518