2. Gene
  3. SRGN - serglycin Gene

SRGN - serglycin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PPG; PRG; PRG1

Gene ID: 5552 | Gene type: protein coding

About SRGN

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,087,603-69,104,811 (from NCBI)

This gene has 2 transcripts (splice variants) and 110 orthologues. Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues.

Summary

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated Apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

SRGN Products(3)

mRNA Protein Name
NM_001321053.2 NP_001307982.1 serglycin isoform 1 precursor
NM_001321054.1 NP_001307983.1 serglycin isoform 2
NM_002727.4 NP_002718.2 serglycin isoform 1 precursor

SRGN Protein Structure

Serglycin

Serglycin: Serglycin (3 - 152)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

serglycin

hematopoetic proteoglycan core peptide

Recombinant SRGN Proteins

Cat. No. Product Name Accession Purity
HY-P76058 Serglycin/SRGN Protein, Human (HEK293, His-Myc) P10124 (M1-L158) ≥95%
HY-P76059 Serglycin/SRGN Protein, Human (HEK293, His) CAA34900.1/AAA60179.1 (Y28-L158) ≥95%

Related Diseases

Diseases Alias
Mucinoses
Central Corneal Ulcer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13766 SRGN Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SRGN MGD MGI:97756
Bos taurus SRGN VGNC VGNC:35280
Canis familiaris SRGN VGNC VGNC:46803
Macaca mulatta SRGN VGNC VGNC:106106
Rattus norvegicus SRGN RGD RGD:619969
Others SRGN NCBI