RNF126 - ring finger protein 126 Gene

Homo sapiens

Gene ID: 55658 | Gene type: protein coding

About RNF126

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:647,526-663,214 (from NCBI)

This gene has 7 transcripts (splice variants), 262 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.1), spleen (RPKM 11.1) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

RNF126 Products(2)

mRNA	Protein	Name
NM_001366018.1	NP_001352947.1	E3 ubiquitin-protein ligase RNF126 isoform 2
NM_194460.3	NP_919442.1	E3 ubiquitin-protein ligase RNF126 isoform 1

RNF126 Protein Structure

zinc_ribbon_9

zf-RING_2

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF126

Related Diseases

Diseases

Alias

Friedreich Ataxia

Friedreich Ataxia 1	FRDA
Friedreich Ataxia With Retained Reflexes	Frda1
Fa	Friedreich'S Ataxia
Hereditary Spinal Ataxia	Fa1
Friedreich'S Tabes	Hereditary Spinal Sclerosis
Spinocerebellar Ataxia, Friedreich	Friedreich Spinocerebellar Ataxia
Friedrich'S Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163639	BRD4 degrader-2	Inhibitor	/	Unkown
HY-RS12045	RNF126 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF126	VGNC	VGNC:34018
Canis familiaris	RNF126	VGNC	VGNC:84866
Rattus norvegicus	RNF126	RGD	RGD:1306011
Mus musculus	RNF126	MGD	MGI:1917544
Felis catus	RNF126	VGNC	VGNC:102685
Macaca mulatta	RNF126	VGNC	VGNC:76791

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