ARHGEF40 - Rho guanine nucleotide exchange factor 40 Gene

Homo sapiens

Also known as SOLO

Gene ID: 55701 | Gene type: protein coding

About ARHGEF40

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,061,264-21,090,248 (from NCBI)

This gene has 8 transcripts (splice variants), 107 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 21.4), adrenal (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014]

ARHGEF40 Products(3)

mRNA	Protein	Name
NM_001278529.2	NP_001265458.1	rho guanine nucleotide exchange factor 40 isoform 2
NM_001278530.2	NP_001265459.1	rho guanine nucleotide exchange factor 40 isoform 3
NM_018071.5	NP_060541.3	rho guanine nucleotide exchange factor 40 isoform 1

ARHGEF40 Protein Structure

RhoGEF

0
300
600
900
1200
1519 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 40

Rho guanine nucleotide exchange factor (GEF) 40

Related Diseases

Diseases

Alias

Usher Syndrome, Type Id

Usher Syndrome Type 1d	USH1D
Usher Syndrome, Type 1d	Usher Syndrome Type Id
Usher Syndrome, Type Id/F, Digenic	Usher Syndrome, Type 1d/F Digenic
Usher Syndrome 1d	Usher'S Syndrome Type 1d
Usher Syndrome 1d/F	USH1DF
Ush1d/F	Usher'S Syndrome Type 1h
Usher Syndrome 1h	Usher Syndrome Type Ih
Usher Syndrome, Type 1d/F

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00961	ARHGEF40 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGEF40	VGNC	VGNC:38089
Bos taurus	ARHGEF40	VGNC	VGNC:26118
Felis catus	ARHGEF40	VGNC	VGNC:59908
Mus musculus	ARHGEF40	MGD	MGI:2685515
Rattus norvegicus	ARHGEF40	RGD	RGD:1308093
Macaca mulatta	ARHGEF40	VGNC	VGNC:69907

Name
Email *

	Sorry, but the email address you supplied was invalid.