FAR2 - fatty acyl-CoA reductase 2 Gene

Homo sapiens

Also known as MLSTD1; SDR10E2; HEL-S-81

Gene ID: 55711 | Gene type: protein coding

About FAR2

Cytogenetic location: 12p11.22 Genomic coordinates (GRCh38): 12:29,149,278-29,335,616 (from NCBI)

This gene has 25 transcripts (splice variants), 251 orthologues and 1 paralogue. Broad expression in colon (RPKM 8.7), small intestine (RPKM 5.0) and 22 other tissues.

Summary

This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase Enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

FAR2 Products(3)

mRNA	Protein	Name
NM_001271783.2	NP_001258712.1	fatty acyl-CoA reductase 2 isoform 1
NM_001271784.2	NP_001258713.1	fatty acyl-CoA reductase 2 isoform 2
NM_018099.5	NP_060569.3	fatty acyl-CoA reductase 2 isoform 1

FAR2 Protein Structure

NAD_binding_4

Sterile

0
100
200
300
400
515 a.a.

Protein Preferred Names

Protein Names

fatty acyl-CoA reductase 2

epididymis secretory protein Li 81

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 27

RP27	Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type
Retinal Degeneration Autosomal Recessive Clumped Pigment Type	RDCP
Clumped Pigmentary Retinal Degeneration	Retinitis Pigmentosa, Type 27

Necatoriasis

Miner'S Anaemia	Negro Cachexia
Dochmiasis	Ground Itch Disease
Brickmaker'S Chlorosis	Coolie Itch Anaemia
Cachexia Aquosa	Dew Itch Anaemia
Brickmaker'S Anaemia	Tunnel Worker'S Anaemia
Egyptian Anaemia	Tunnel Worker'S Disease
Miner'S Cachexia	Greisinger Disease
Tropical Chlorosis	Egyptian Chlorosis
Tunnel Anaemia	Dochmiosis
Necatorosis	African Cachexia
Water Itch Anaemia	Infection Due To Necator Americanus
St Gotthard Disease	Gotthard Tunnel Disease

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04745	FAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04748	FARS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FAR2	VGNC	VGNC:28864
Felis catus	FAR2	VGNC	VGNC:62148
Mus musculus	FAR2	MGD	MGI:2687035
Rattus norvegicus	FAR2	RGD	RGD:1565966
Macaca mulatta	FAR2	VGNC	VGNC:81403
Canis familiaris	FAR2	VGNC	VGNC:40729

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