DDX28 - DEAD-box helicase 28 Gene

Homo sapiens

Also known as MDDX28

Gene ID: 55794 | Gene type: protein coding

About DDX28

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,020,916-68,023,232 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 38 paralogues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]

DDX28 Products(1)

mRNA	Protein	Name
NM_018380.4	NP_060850.2	probable ATP-dependent RNA helicase DDX28

DDX28 Protein Structure

DEAD

Helicase_C

0
100
200
300
400
500
540 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX28

DEAD (Asp-Glu-Ala-Asp) box polypeptide 28

Related Diseases

Diseases

Alias

Spastic Paraplegia 7, Autosomal Recessive

SPG7	Hereditary Spastic Paraplegia 7
Spastic Paraplegia Type 7	Spastic Paraplegia 7
Hereditary Spastic Paraplegia, Paraplegin Type	Autosomal Recessive Spastic Paraplegia 7
Hereditary Spastic Paraplegia Paraplegin Type	Spastic Paraplegia-7
Paraplegia, Spastic, Autosomal Recessive, Type 7	Spastic Paraplegia, Hereditary
Autosomal Recessive Hereditary Spastic Paraplegia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03642	DDX28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DDX28	VGNC	VGNC:61404
Mus musculus	DDX28	MGD	MGI:1919236
Rattus norvegicus	DDX28	RGD	RGD:1311976
Canis familiaris	DDX28	VGNC	VGNC:39853
Macaca mulatta	DDX28	VGNC	VGNC:71643
Bos taurus	DDX28	VGNC	VGNC:27962

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