ADAP2 - ArfGAP with dual PH domains 2 Gene

Homo sapiens

Also known as CENTA2; cent-b; HSA272195

Gene ID: 55803 | Gene type: protein coding

About ADAP2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,921,945-30,959,322 (from NCBI)

This gene has 11 transcripts (splice variants), 250 orthologues and 28 paralogues. Broad expression in spleen (RPKM 10.3), placenta (RPKM 9.9) and 23 other tissues.

Summary

The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]

ADAP2 Products(4)

mRNA	Protein	Name
NM_001346712.2	NP_001333641.1	arf-GAP with dual PH domain-containing protein 2 isoform 1
NM_001346714.2	NP_001333643.1	arf-GAP with dual PH domain-containing protein 2 isoform 3
NM_001346716.2	NP_001333645.1	arf-GAP with dual PH domain-containing protein 2 isoform 4
NM_018404.3	NP_060874.1	arf-GAP with dual PH domain-containing protein 2 isoform 2

ADAP2 Protein Structure

ArfGap

PH_11

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

arf-GAP with dual PH domain-containing protein 2

centaurin beta

Related Diseases

Diseases

Alias

Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome	17q11 Microdeletion Syndrome
Neurofibromatosis Type 1 Microdeletion Syndrome	Van Asperen Syndrome
Del(17)(Q11)	Monosomy 17q11
Chromosome 17q11.2 Deletion Syndrome, 1.4mb

Neurofibromatosis-Noonan Syndrome

NFNS	Neurofibromatosis Type 1
Neurofibromatosis With Noonan Phenotype	Nf1
Von Recklinghausen Disease	Neurofibromatosis Type 1-Noonan Syndrome
Noonan Neurofibromatosis Syndrome	Recklinghausen'S Disease
Noonan-Neurofibromatosis Syndrome	Fibromatosis Multiple Non Ossifying
Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots	Jaffe Campanacci Syndrome
Type 1 Neurofibromatosis	Neurofibromatosis 1
Peripheral Neurofibromatosis	Recklinghausen Disease, Nerve
Jaffe-Campanacci Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00316	ADAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAP2	RGD	RGD:708487
Canis familiaris	ADAP2	VGNC	VGNC:37611
Felis catus	ADAP2	VGNC	VGNC:59605
Macaca mulatta	ADAP2	VGNC	VGNC:69430
Mus musculus	ADAP2	MGD	MGI:2663075
Bos taurus	ADAP2	VGNC	VGNC:25634

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