2. Gene
  3. PRKCH - protein kinase C eta Gene

PRKCH - protein kinase C eta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PKCL; PKC-L; PRKCL; uORF2; nPKC-eta

Gene ID: 5583 | Gene type: protein coding

About PRKCH

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:61,187,468-61,550,976 (from NCBI)

This gene has 27 transcripts (splice variants), 241 orthologues, 9 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 18.8), spleen (RPKM 14.7) and 24 other tissues.

Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]

PRKCH Products(8)

mRNA Protein Name
NM_006255.5 NP_006246.2 protein kinase C eta type
XM_024449661.2 XP_024305429.1 protein kinase C eta type isoform X4
XM_024449662.2 XP_024305430.1 protein kinase C eta type isoform X4
XM_011536957.2 XP_011535259.1 protein kinase C eta type isoform X6
XM_011536955.2 XP_011535257.1 protein kinase C eta type isoform X3
XM_047431586.1 XP_047287542.1 protein kinase C eta type isoform X5
XM_011536954.4 XP_011535256.1 protein kinase C eta type isoform X2
XM_047431585.1 XP_047287541.1 protein kinase C eta type isoform X1

PRKCH Protein Structure

C2

C2: C2 domain (12 - 101)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (172 - 225)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (246 - 297)

Pkinase

Pkinase: Protein kinase domain (355 - 613)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (635 - 679)

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  • 683 a.a.
Protein Preferred Names Protein Names

protein kinase C eta type

Protein uPEP2

Related Diseases

Diseases Alias
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident
Amphetamine Abuse
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11131 PRKCH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11132 Prkch Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11133 Prkch Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRKCH MGD MGI:97600
Canis familiaris PRKCH VGNC VGNC:44981
Rattus norvegicus PRKCH RGD RGD:621888
Bos taurus PRKCH VGNC VGNC:33332
Macaca mulatta PRKCH VGNC VGNC:84424
Felis catus PRKCH VGNC VGNC:104609
Others PRKCH NCBI