KIZ - kizuna centrosomal protein Gene

Homo sapiens

Also known as RP69; HT013; Kizuna; PLK1S1; C20orf19; NCRNA00153

Gene ID: 55857 | Gene type: protein coding

About KIZ

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:21,125,975-21,246,622 (from NCBI)

This gene has 15 transcripts (splice variants), 179 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 20.1), ovary (RPKM 11.1) and 25 other tissues.

Summary

The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

KIZ Products(7)

mRNA	Protein	Name
NM_001163022.3	NP_001156494.1	centrosomal protein kizuna isoform 2
NM_001163023.3	NP_001156495.1	centrosomal protein kizuna isoform 3
NM_001276389.2	NP_001263318.1	centrosomal protein kizuna isoform 4
NM_001352434.2	NP_001339363.1	centrosomal protein kizuna isoform 5
NM_001352435.2	NP_001339364.1	centrosomal protein kizuna isoform 6
NM_001352436.2	NP_001339365.1	centrosomal protein kizuna isoform 7
NM_018474.6	NP_060944.3	centrosomal protein kizuna isoform 1

Protein Preferred Names

Protein Names

centrosomal protein kizuna

polo-like kinase 1 substrate 1

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 69

RP69	Retinitis Pigmentosa, Type 69

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Pica Disease

Pica

Preretinal Fibrosis

Cellophane Maculopathy	Macular Puckering Of Retina
Macular Retinal Puckering	Epiretinal Membrane

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07323	KIZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIZ	MGD	MGI:2684960
Rattus norvegicus	KIZ	RGD	RGD:1307071
Canis familiaris	KIZ	VGNC	VGNC:42424
Macaca mulatta	KIZ	VGNC	VGNC:73838
Bos taurus	KIZ	VGNC	VGNC:30620
Felis catus	KIZ	VGNC	VGNC:63125

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